This proposal for Cancer Center Support Grant (Comprehensive) for the Fred Hutchinson Cancer Research Center of Seattle is to develop support for key personnel, centralized services, jointly used equipment and beginning programs in research hospitalization and community affairs. Basic science programs involving Tumor Immunology, Biochemical Oncology, Carcinogenesis and other Related Organic Chemistry, Medical Oncology with various subdivisions, projected Viral Oncology, Oncologic Pharmacology, Pathology and Electronmicroscopy, Visiting Scientists, Surgical Oncology are presently underway. Other programs in the Extramural area will involve Biostatistics/Epidemiology, Library Services and Information, Rehabilitation Medicine and the Pacific Northwest Cooperative Cancer Study Group. The Center itself will function not only as an architectural but as a programmatic focus for other aspects of cancer research involving Therapeutic Radiology, Pediatric Oncology, Cancer Detection Program in conjunction with the American Cancer Society, research activities in the Pacific Northwest Research Foundation and planning to develop further activities of the Center. Construction of the Center will commence in September of 1973 with completion anticipated in early 1975. A strong community support from American Cancer Society, University of Washington, regional and local hospitals and practicing physicians has been obtained. It is anticipated that the Fred Hutchinson Cancer Research Center will function as a truly comprehensive cancer center for the Pacific Northwest region with strong cooperative ties with the State of Oregon.